Preventing against air leakage is great, but the only way to keep dust and debris out of a duct system would be to completely seal off the return-air side of the system, which would render the system useless. Cold-air returns will always pull dust and other particles into the system. A high-MERV rated filter is definitely a good idea, but it does nothing to keep the return side of the system clean. Definitely agree though to use foil tape to seal seams, etc. Duct tape dries out over time and as it does can actually add more particles to the air.
Metal is way better than flex duct or ductboard. It gets better airflow, holds up to critters and duct cleaners. I know of no hvac company here that cleans ductwork. (there probably is one somewhere) The mfg's of duct cleaning equipment keep trying to sell us hvac people on their benefits and profit potential but most all hvac people know that unless you have metal ductwork you are NOT doing the customer any favors.
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