WELL, this summer when I opened them up we had black dust spewing from one of the upstairs vents. It resembled the fuzz that comes off new towels. This prompted us to look into duct cleaning. We heard from someone who had it done several times, said it was worthwhile, and knew of a firm that did a good job. Clean Air America sent a single technician for the appointment and after counting registers and ducts gave me a price of $360.00 which included “sanitizing” the system (a $99 additional fee per can used). The small size of the plenum forced him to connect the 8” round vacuum hose from the truck to the 10” square opening from our humidifier unit. In hindsight, a mistake since it reduced the “negative” pressure in the system.
An alternative to packaged systems is the use of separate indoor and outdoor coils in split systems. Split systems are preferred and widely used worldwide except in North America. In North America, split systems are most often seen in residential applications, but they are gaining popularity in small commercial buildings. The split systems are a great choice for small buildings where ductwork is not feasible or where the space conditioning efficiency is of prime concern [20]. The benefits of ductless air conditioning systems include easy installation, no ductwork, greater zonal control, flexibility of control and quiet operation [21]. In space conditioning, the duct losses can account for 30% of energy consumption [22]. The use of minisplit can result in energy savings in space conditioning as there are no losses associated with ducting.
The cooling coils the air comes into contact with appear to need UV-C lights on them in humid climates. That's the biggest thing. If the ducts have never been cleaned, then getting that done goes without saying. But those coils need to be cleaned, disinfected, and then UV-C light(s) installed to prevent mold & bacteria build-up in the future on them. That appears to be chiefly responsible for the dirty laundry and/or sour milk smell coming from forced-air AC systems in humid regions.
Central, "all-air" air-conditioning systems (or package systems) with a combined outdoor condenser/evaporator unit are often installed in North American residences, offices, and public buildings, but are difficult to retrofit (install in a building that was not designed to receive it) because of the bulky air ducts required. (Minisplit ductless systems are used in these situations.) Outside of North America, packaged systems are only used in limited applications involving large indoor space such as stadiums, theatres or exhibition halls.

They did come out Tuesday and completed the job.  We called the office to ask for a breakdown of the cost and they said the tech would call us back, but that never happened.  Eventually Alberto called and explained the breakdown.  One reason it was more was they used an OEM circuit board, rather than an aftermarket part.  I agree with this but it would have been better if this had been explained from the beginning.  All in all, it still seems like their price is a bit on the high side, but they did a good job and used OEM parts so I'm giving them four stars.

Filtration systems -- A second-stage filter is sometimes inserted & used to remove particulates such as pets, smoking or cooking, as well as other odors, gases, and VOCs (volatile organic compounds). A HEPA filter is also available to remove spores, pollens, bacteria and lung-damaging particles. There are also systems that use ultraviolet (UV) light to protect against bacteria and germs.
Multiple inventions within this time frame preceded the beginnings of first comfort air conditioning system, which was designed in 1902 by Alfred Wolff (Cooper, 2003) for the New York Stock Exchange, while Willis Carrier equipped the Sacketts-Wilhems Printing Company with the process AC unit the same year. Coyne College was the first school to offer HVAC training in 1899.[12]

If you believe that the AC's not working or you're getting little or no cold air, check these three things first. Make sure all the registers in the house are wide open. Then be sure the furnace filter is clean. Then go outside and clean off the condenser coils (Photo 2). If several registers were closed or the filter was clogged, the reduced airflow could have caused the evaporator coil to ice up and stop cooling your home. If you've changed the filter and opened all the registers and you're still not getting airflow at the registers, deice the A-coil. Move the thermostat mode switch from “Cooling” to “Off” and move the fan switch from “Auto” to “On.” Let the blower run for at least 30 minutes or until there's good airflow at the registers. Then turn the AC back on to test it. If it works for the next 12 hours, you've solved the problem.