The jury is out on whether or not cleaning your air ducts and vents has a significant enough impact to be necessary. A proven connection between immaculate duct systems and air quality in the home has not been made. However, if your vents display any of the signs listed above, cleaning would certainly be in your best interest. Allowing mold, debris and bacteria to fester could create bigger problems down the line. If having your system disinfected is within your budget, you may prefer to take care of these issues rather than ignore them.
I am NADCA Certified Air Systems Cleaning Specialist. Over the years I have learned on simple answer to this questions: there air duct cleaners and there are pretenders. There will be no benefit at all if you use on the very cheap pretender because they will not really clean anything. On the other hand if you call a qualified air duct cleaner with a NADCA Certification you will, like 99% of my customers, report improvement with your respiratory problems, you will see less dust and the job will pay for itself with energy savings and repair prevention.
An important component of natural ventilation is air change rate or air changes per hour: the hourly rate of ventilation divided by the volume of the space. For example, six air changes per hour means an amount of new air, equal to the volume of the space, is added every ten minutes. For human comfort, a minimum of four air changes per hour is typical, though warehouses might have only two. Too high of an air change rate may be uncomfortable, akin to a wind tunnel which have thousands of changes per hour. The highest air change rates are for crowded spaces, bars, night clubs, commercial kitchens at around 30 to 50 air changes per hour.[17]
Some of the research I have done suggests to have your ducts cleaned when you first purchase a new home to remove drywall dust. Maintain your system well and you shouldn't have to do it again until you want to sell. Those are the two times cleaning was suggested. So for peace of mind maybe it is a good idea to do it even if you buy a used home and then maybe every 5-10 years.

Compressor -- Compressors are outdoor components in your system. The compressor is the pump that circulates the refrigerants through the air-conditioner. You can hear it when it's running so you'll know if it's working just by listening. If it starts getting louder, your compressor is about to fail. If it makes no sound when it should be on, it has already failed. Compressors fail for a number of reasons. Most often they fail due to strain from another failed part such as the fan motor. Electrical storms can also damage compressors. If the sound from the compressor gets louder or if you see a decrease in performance, you should have your compressor checked. A failed compressor will not heat or cool your house.
"Customer service was great, and the price was in-line with other places, and fast service. We had a whole replacement of the outside and inside. I would have liked to see a better install for the furnace and new thermostat - the new thermostat should have gone where the old one was, and even tho the new furnace was a tight fit, they didn't offer to come back and repair the case molding, or give me a discount on the damage done, and I believe they should have put a disconnect box on the outside of the home, to make it easier for any future repairs needed. Other than that, am very happy with the cooling and heating!"