The cooling coils the air comes into contact with appear to need UV-C lights on them in humid climates. That's the biggest thing. If the ducts have never been cleaned, then getting that done goes without saying. But those coils need to be cleaned, disinfected, and then UV-C light(s) installed to prevent mold & bacteria build-up in the future on them. That appears to be chiefly responsible for the dirty laundry and/or sour milk smell coming from forced-air AC systems in humid regions.
In addition, the service provider may propose applying chemical biocides, designed to kill microbiological contaminants, to the inside of the duct work and to other system components. Some service providers may also suggest applying chemical treatments (sealants or other encapsulants) to encapsulate or cover the inside surfaces of the air ducts and equipment housings because they believe it will control mold growth or prevent the release of dirt particles or fibers from ducts. These practices have yet to be fully researched and you should be fully informed before deciding to permit the use of biocides or chemical treatments in your air ducts. They should only be applied, if at all, after the system has been properly cleaned of all visible dust or debris.

Before we get to HVAC installation prices, we will first need to briefly discuss some terms, definitions, and factors that will affect how an honest HVAC installation company determines their prices. Notice that I said honest. Unfortunately, there are dishonest people out there. There always have been, there always will be, and there is a good chance that you had an experience with such a contractor, which is what drove you to read this article. I can’t teach you how to tell if someone is honest, but I can give you the knowledge to help you decide. Take a look at How to Choose an HVAC Contractor for tips on what to look for.
Your cleaning service should involve all aspects of your duct work to maximize energy efficiency and air quality. This includes attending to the heat exchanger, blower, drain pan, plenum and coils as well. In the process, your service provider may find that you're facing larger issues than debris and build-up. The professional may recommend having your furnace repaired if they notice, for example, damage to your heat exchanger or blower motor. Generally, a furnace repair costs between $130 and $500. They may also find that an A/C coil needs to be replaced rather than cleaned and would then recommend A/C repair.

I called a company name “GREEN RHVAC” with their $29.00 one system air duck cleaning. When the guy came with a truck I asked him to tell me how much he will charge and he said that if he gave me price and I didn’t want the service then he would charge me $89 or he would tell me how much he charge me after he finished the work. I immoderately sense that I made mistake to call him to my house. To cut my lost I asked him to give me the price and it was $1600 for two systems house. I paid $100 to him for my lesson to learn and search online to find this site is very helpfully and I should do it before to call anyone for air duck cleaning.
I called a company name “GREEN RHVAC” with their $29.00 one system air duck cleaning. When the guy came with a truck I asked him to tell me how much he will charge and he said that if he gave me price and I didn’t want the service then he would charge me $89 or he would tell me how much he charge me after he finished the work. I immoderately sense that I made mistake to call him to my house. To cut my lost I asked him to give me the price and it was $1600 for two systems house. I paid $100 to him for my lesson to learn and search online to find this site is very helpfully and I should do it before to call anyone for air duck cleaning.
There are many interesting comments from several informed individuals. The question that has not been answered is how do duct systems get dusty and dirty? As a RESNET Home Energy Rater, I perform pressure tests on homes and duct systems, and the one common thread is . . . most air delivery sytems have large amounts of air leakage. The solution is to seal the duct system, and pay particular attention to the return duct system and ductwork near the air handler (the 'blower'). As others have said, a captive (sealed) duct system with proper filter maintenance should be more then adequate for most occupants. For those who have allergy, asthma, or other breathing problems, a filter with a higher MERV rating (number should be listed on the package) or a HEPA filter are good choices. These filters will capture smaller particulates and should improve the indoor air quality. Again, make certain that the entire duct system is sealed, preferably with mastic, second choice UL-181 foil tape - never use cloth duct (also known as duck) tape.

If not properly installed, maintained and operated, these components may become contaminated with particles of dust, pollen or other debris. If moisture is present, the potential for microbiological growth (e.g., mold) is increased and spores from such growth may be released into the home's living space. Some of these contaminants may cause allergic reactions or other symptoms in people if they are exposed to them. If you decide to have your heating and cooling system cleaned, it is important to make sure the service provider agrees to clean all components of the system and is qualified to do so. Failure to clean a component of a contaminated system can result in re-contamination of the entire system, thus negating any potential benefits. Methods of duct cleaning vary, although standards have been established by industry associations concerned with air duct cleaning. Typically, a service provider will use specialized tools to dislodge dirt and other debris in ducts, then vacuum them out with a high-powered vacuum cleaner.
The HVAC installation costs below are based on residential installations only, and are priced for a single unit. Two units should be about twice the price. “Tim, shouldn’t there be a discount?” If people start giving you discounts, they are probably charging you too much to begin with.  That’s our philosophy anyway. Twice the parts and time should be twice the price from a fair contractor. The prices listed include component parts (with warranty), labor, and all materials for a complete HVAC installation.
As for the price I think my review was fair in stating what value we got for what I deemed to be a slightly higher price than others might charge.  I did not take any stars off for the price, and still am not, but I am taking another star off because of Alberto's comments, which are deceptive and not the same thing he told me in person.  Alberto, I suggest you stick with the high road in the future.
Sounds like your first hvac company was ripping you off. Ask your new company to go to your coil and see if there is a leak. If there isn't the last company was just lining their pockets. If you have had ducts unhooked for a long time I would recommend duct cleaning, trust me I'm not a fan of duct cleaning myself. I have done hvac for 20 yrs. in GA. When I just bought a home built in 1996, we had all the ducts replaced immediately.
An important component of natural ventilation is air change rate or air changes per hour: the hourly rate of ventilation divided by the volume of the space. For example, six air changes per hour means an amount of new air, equal to the volume of the space, is added every ten minutes. For human comfort, a minimum of four air changes per hour is typical, though warehouses might have only two. Too high of an air change rate may be uncomfortable, akin to a wind tunnel which have thousands of changes per hour. The highest air change rates are for crowded spaces, bars, night clubs, commercial kitchens at around 30 to 50 air changes per hour.[17]
The Chartered Institution of Building Services Engineers is a body that covers the essential Service (systems architecture) that allow buildings to operate. It includes the electrotechnical, heating, ventilating, air conditioning, refrigeration and plumbing industries. To train as a building services engineer, the academic requirements are GCSEs (A-C) / Standard Grades (1-3) in Maths and Science, which are important in measurements, planning and theory. Employers will often want a degree in a branch of engineering, such as building environment engineering, electrical engineering or mechanical engineering. To become a full member of CIBSE, and so also to be registered by the Engineering Council UK as a chartered engineer, engineers must also attain an Honours Degree and a master's degree in a relevant engineering subject.
Wiring up the thermostat is usually pretty straightforward if an old one is being replaced. If a thermostat is being put in where one had never been before, that could involve running new wiring. The placement of the thermostat is also important so that its sensors can get an accurate reading of the temperature. A thermostat that is blocked by a bookcase or other large furniture will not get a good reading and will not perform efficiently.
Ventilating or ventilation (the V in HVAC) is the process of exchanging or replacing air in any space to provide high indoor air quality which involves temperature control, oxygen replenishment, and removal of moisture, odors, smoke, heat, dust, airborne bacteria, carbon dioxide, and other gases. Ventilation removes unpleasant smells and excessive moisture, introduces outside air, keeps interior building air circulating, and prevents stagnation of the interior air.

Bigger is not necessarily better when it comes to HVAC systems, and smaller isn't always more efficient. If you have too small of a system, your system will be running constantly as it tries to keep up with the temperature. If you have too large of a system, it won't run long enough to keep up with the humidity. In order to handle both temperature and humidity efficiently, an HVAC system should run for around 30 minutes at a time. If your system is staying on too long or shutting off after only around 10 minutes, you are not getting efficient performance.
The performance of vapor compression refrigeration cycles[26] is limited by thermodynamics. These air conditioning and heat pump devices move heat rather than convert it from one form to another, so thermal efficiencies do not appropriately describe the performance of these devices. The Coefficient-of-Performance (COP) measures performance, but this dimensionless measure has not been adopted. Instead, the Energy Efficiency Ratio (EER) has traditionally been used to characterize the performance of many HVAC systems. EER is the Energy Efficiency Ratio based on a 35 °C (95 °F) outdoor temperature. To more accurately describe the performance of air conditioning equipment over a typical cooling season a modified version of the EER, the Seasonal Energy Efficiency Ratio (SEER), or in Europe the ESEER, is used. SEER ratings are based on seasonal temperature averages instead of a constant 35 °C (95 °F) outdoor temperature. The current industry minimum SEER rating is 14 SEER.[27][dead link]
I believe a $3 [sic] pleated cotton filter is all that is ever needed to keep a system running top notch. A cleaning of the blower squirrel cage and of the evaporator [indoor] coil may be needed one time if fiberglass or no filters have been previously used. The return air grille [or grilles] need vacuumed off occasionally, as they are upstream from the filter. The $3 filter should be changed every 3 months [rule of thumb]....and most of them have a little white square on the cardboard frame to write install date.....and the arrow should point into the duct [if at filter grille]....or towards the furnace [if in ductwork slot]...or towards the blower [if in blower compartment]. My two cents.....
I paid $49 for a groupon. When the guy came today, he did an inspection first and said the ductwork first needed to be treated for mold; $348 for a spray that would last 8 months or $680 for an UV light purifier that would last 2 years. Also, the furnace needed to be cleaned for another $260. When I told him to just clean the ductwork, he said I would owe an additional $305 because the groupon was only good for 1 return and I had 2. I sent him packing with no services performed. Thankfully I am only out of $49! I will complain to groupon.
1. Ducts need cleaning mostly because they were not installed properly. There should be regulatory inpection and approval of clean and proper duct works on new houses. I was extremely unpset when I looked and found significant amounts of construction dust in parts of the ducts in my new house. There is apparently no way to hold the bullder to be responsible for clean ducts.
Most people are now aware that indoor air pollution is an issue of growing concern and increased visibility. Many companies are marketing products and services intended to improve the quality of your indoor air. You have probably seen an advertisement, received a coupon in the mail, or been approached directly by a company offering to clean your air ducts as a means of improving your home's indoor air quality. These services typically — but not always — range in cost from $450 to $1,000 per heating and cooling system, depending on:

Refrigerant Metering Device -- Every HVAC system has one of these, and heat pumps have two. They regulate the amount of refrigerant going through your air-conditioner. If it fails, either too much or too little refrigerant will course along the lines and either not perform well or will overwhelm the compressor and cause it to fail. A total failure of this component will result in a complete loss of operation.
Clean the condenser fan blades before the start of the cooling season. Brush any dust or debris off gently and then uncover the condenser coils, gently cleaning the dirty side. Then wrap the motor and other electrical components in plastic bags and gently spray from the inside with a hose. Now check the base pan under the unit and clear it out of any debris that has gathered.
All of you have dentists, you have doctors, you have preachers, you have mechanics. You don’t have to know everything about everything but you have to have people in your life that you can trust. Don’t just open up the phone book and pick a mechanical (HVAC) contractor. Call your friends and family and ask for referrals. There are no black and white (scam or not a scam) answers here.
The HVAC industry is a worldwide enterprise, with roles including operation and maintenance, system design and construction, equipment manufacturing and sales, and in education and research. The HVAC industry was historically regulated by the manufacturers of HVAC equipment, but regulating and standards organizations such as HARDI, ASHRAE, SMACNA, ACCA, Uniform Mechanical Code, International Mechanical Code, and AMCA have been established to support the industry and encourage high standards and achievement.

Duct cleaning has never been shown to actually prevent health problems. Neither do studies conclusively demonstrate that particle (e.g., dust) levels in homes increase because of dirty air ducts. This is because much of the dirt in air ducts adheres to duct surfaces and does not necessarily enter the living space. It is important to keep in mind that dirty air ducts are only one of many possible sources of particles that are present in homes. Pollutants that enter the home both from outdoors and indoor activities such as cooking, cleaning, smoking, or just moving around can cause greater exposure to contaminants than dirty air ducts. Moreover, there is no evidence that a light amount of household dust or other particulate matter in air ducts poses any risk to your health.