If the system is sealed air-tight and a really good filtering system is in place then you should NEVER have to clean your ductwork. Most dust people see in their homes (on beds furniture etc....) is broken down insulation that is being blown into the home from the attic (venturi effect) where the duct bucket (box etc...) is not sealed at the sheetrock ceiling. On the return side, ANY leaks in the ductwork will pull hot attic air and dust into the system, clogging up everything.
Filtration systems -- A second-stage filter is sometimes inserted & used to remove particulates such as pets, smoking or cooking, as well as other odors, gases, and VOCs (volatile organic compounds). A HEPA filter is also available to remove spores, pollens, bacteria and lung-damaging particles. There are also systems that use ultraviolet (UV) light to protect against bacteria and germs.
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